Mike Lee S. Oral Bioavailability Assessment. Basics and Strategies for Drug Discovery and Development

author Mike Lee S.
isbn 9781118916940
13879.71 РУБ
Описание:

which is an underappreciated and complicated area of drug development • Includes chapters about pharmacokinetic modelling, • Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability • Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development • Explains how preclinical animal models – used in preclinical testing – and in vitro tools translate to humans, this book describes the basics and challenges of oral bioavailability – one of the most significant hurdles in drug discovery and development, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) • Has tutorials for applying strategies to medicinal chemistry practices of drug discovery/development.Specifically geared to personnel in the pharmaceutical and biotechnology industries



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